.png){kind=icon}
返回
SMDB: a Spatial Multimodal Data Browser
.png){kind=icon}
OA
AI
DOI：10.1093/nar/gkad413.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Understanding the relationship between fine-scale spatial organization and biological function necessitates a tool that effectively combines spatial positions, morphological information, and spatial transcriptomics (ST) data. We introduce the Spatial Multimodal Data Browser (SMDB,), a robust visualization web service for interactively exploring ST data. By integrating multimodal data, such as hematoxylin and eosin (H&E) images, gene expression-based molecular clusters, and more, SMDB facilitates the analysis of tissue composition through the dissociation of two-dimensional (2D) sections and the identification of gene expression-profiled boundaries. In a digital three-dimensional (3D) space, SMDB allows researchers to reconstruct morphology visualizations based on manually filtered spots or expand anatomical structures using high-resolution molecular subtypes. To enhance user experience, it offers customizable workspaces for interactive exploration of ST spots in tissues, providing features like smooth zooming, panning, 360-degree rotation in 3D and adjustable spot scaling. SMDB is particularly valuable in neuroscience and spatial histology studies, as it incorporates Allen's mouse brain anatomy atlas for reference in morphological research. This powerful tool provides a comprehensive and efficient solution for examining the intricate relationships between spatial morphology, and biological function in various tissues.
Keyword:
GENE-EXPRESSION
STRIATUM
FRAMEWORK
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
13.1
论文数:
3.6W
被引数:
29.0W
机构
引用论文
ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.png)
SCIENTIFIC REPORTSOAAI
SCIENTIFIC REPORTSIF3.9
OAAI分享收藏Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue基于杂交的原位测序 (HybISS) 用于人和小鼠脑组织中的空间分辨转录组学NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq单细胞rna-seq揭示的小鼠纹状体的细胞分类学CELL REPORTSOAAI
CELL REPORTSIF6.9
OAAI分享收藏The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.OAAI
OAAI分享收藏Acute experimental allergic encephalomyelitis in the mouse: Immunopathology of the developing lesion
PREAI
分享收藏spatialLIBD: an R/Bioconductor package to visualize spatially-resolved transcriptomics dataspatialLIBD: 一个R/Bioconductor软件包，用于可视化空间分辨的转录组学数据BMC GENOMICSOAAI
BMC GENOMICSIF3.7
OAAI分享收藏
查看更多内容