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SMMILe enables accurate spatial quantification in digital pathology using multiple-instance learning

delete2025-11-19
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OA
AI
Z
Zeyu Gao
Y
Yuxing Dong
H
Hannah Clayton
吴
吴建祥 (Jialun Wu)
J
Jiashuai Liu
C
Chunbao Wang
K
Kai He
T
Tieliang Gong *
C
Chen Li *
M
Mireia Crispin‐Ortuzar *
DOI:10.1038/s43018-025-01060-8delete
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摘要

摘要

En 中文
空间量化是大多数计算病理学任务中的关键步骤,从引导病理学家关注临床兴趣区域到发现新型生物标志物背后的组织表型。为避免手动注释的需求,现代计算病理学方法倾向于采用多实例学习(multiple-instance learning)方法,能够准确预测全视野图像(whole-slide image)标签,尽管这会以牺牲其空间感知能力为代价。本文从数学上证明了,采用实例级聚合(instance-level aggregation)的模型可以在不损害全视野图像预测性能的前提下实现更优的空间量化。随后,我们介绍了一种基于超图块(superpatch)的可测量多实例学习方法SMMILe,并在6种癌症类型、3种高度多样化的分类任务和涉及3,850张全视野图像的8个数据集上对其进行了评估。我们将SMMILe与9种现有方法进行了基准测试,采用了两种不同的编码器——ImageNet预训练编码器和病理学专用基础模型(pathology-specific foundation model),结果表明,在所有情况下,SMMILe均达到或超过了当前最先进的全视野图像分类性能,同时实现了出色的空间量化。Gao等人提出了SMMILe这一基于多实例学习的工具,利用全视野图像进行准确的空间量化而不损害分类性能,并证明其优于当前最先进的方法。
Keyword:
Spatial quantification
Multiple-instance learning
Digital pathology
Whole-slide image classification
Superpatch-based method
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Nature Cancer
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xi’an jiaotong university
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