Soft bioelectronics for wound monitoring and therapy

doi:10.1038/s41528-026-00631-8

Soft bioelectronics for wound monitoring and therapy

2026-08-19

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DOI：10.1038/s41528-026-00631-8

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Soft bioelectronics have emerged as a transformative platform for wound care by enabling continuous, intimate, and multimodal interfacing with dynamic skin environments. This review systematically elaborates the underlying principles of biophysical and biochemical sensors for capturing critical wound parameters. We further discuss therapeutic soft bioelectronics, including electrical stimulation, phototherapy, and acoustic stimulation strategies, together with responsive drug delivery systems that leverage wound microenvironmental cues. Building upon these foundations, we highlight the development of smart wound care architectures that integrate wireless communication, data interpretation and real-time wound assessment with on-demand transdermal therapeutic actuation in both open-loop and closed-loop systems. Finally, we outline the major challenges facing the field, particularly long-term operational stability and the development of truly intelligent closed-loop platforms, and highlight future opportunities for next-generation soft bioelectronic systems capable of autonomously monitoring and managing complex wounds.

Soft bioelectronics for wound monitoring and therapy

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