Spatial distribution of iron in the brain tissue of the substantia nigra pars compacta determined by PIXE analysis

2026-07-03

PRE

Ján Pánik

Martin Kopáni

Silvia Dulanská

Miroslav Ješkovský

Jakub Kaizer

Jakub Zeman

Michal Trnka *

Pavel P. Povinec

DOI：10.1016/j.radphyschem.2026.114216

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• PIXE enabled quantitative macro-scale mapping of iron in brain tissue. • Substantia nigra shows high iron heterogeneity with distinct focal hot spots. • Maximum local iron concentrations reached 3096 ng/mg in non-diseased tissue. • No linear correlation was found between donor age and regional iron levels.

Spatial distribution of iron in the brain tissue of the substantia nigra pars compacta determined by PIXE analysis

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