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Spatial multi-omics landscape of colorectal cancer macro- and micrometastases

delete2026-07-09
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OA
AI
Y
Yang Liu
A
Akshaya Jadhav
Y
Yuwen Pan
J
Jianlong Liao
I
Isha Khanduri
Y
Yunhe Liu
R
Riham Katkhuda
W
Wei Lü
K
Kyung Serk Cho
Z
Zhimin Tong
T
Tieling Zhou
K
Kangyu Lin
B
Baohua Sun
M
Mei Jiang
S
Sharia Hernandez
I
Idania Carolina Lubo Julio
P
Patrick Brennan
G
Guangsheng Pei
K
Kai Yu
Y
Yibo Dai
DOI：10.1016/j.ccell.2026.06.009delete
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Abstract

Abstract

En 中文
• Spatial multi-omics to delineate cellular and molecular architecture of CRC metastases • Micrometastatic tumor cells exhibit early clonal divergence and a stem-like state • Micrometastases are characterized by immunosuppression and T cell exhaustion • CLiMi six-gene signature predicts MRD status, DFS, and chemotherapy resistance

Journal

Cancer Cell cover
Cancer Cell
IF:
44.5
Papers:
413
Citations:
5.6W

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