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Spectrum-effect relationship and network pharmacology reveal key anti-rheumatoid arthritis and attenuated toxicity components of processed curculigo rhizome
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DOI：10.1016/j.jep.2026.122244.png)
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Abstract
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• HPLC fingerprints identified 13 common peaks in raw and wine-processed Curculigo rhizome. • Wine processing enhanced bioactive compound content and reduced nephrotoxici potential compared to raw form. • Both extracts alleviated arthritis symptoms and synovial inflammation in CIA mice dose-dependently. • Spectrum-effect analysis revealed ANA, SAK, CA, and ORC as key anti-rheumatoid arthritis markers. • Network pharmacology and molecular docking identified glycolysis inhibition as potential mechanism.
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