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Squalene alleviates cancer cachexia-induced muscle atrophy and adipose tissue wasting in CT26 tumor-bearing mice
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DOI:10.1016/j.jnutbio.2026.110457.png)
Abstract
En 中文
• Squalene mitigates colon cancer-induced skeletal muscle and adipose wasting. • SQ attenuates muscle wasting via the PI3K/Akt/mTOR signaling pathway. • SQ suppresses systemic inflammation and enhances antioxidant defense. • SQ prevents adipose loss by inhibiting AMPK-mediated lipolysis and thermogenesis.
Keywords:
Squalene
Cancer cachexia
Muscle atrophy
Adipose tissue wasting
Inflammation
Protein turnover
Fat lipolysis
Journal
IF:
4.9
Papers:
4.5K
Citations:
1.4W
