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Stable memory with unstable synapses
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DOI：10.1038/s41467-019-12306-2.png)
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摘要
En 中文
What is the physiological basis of long-term memory? The prevailing view in Neuroscience attributes changes in synaptic efficacy to memory acquisition, implying that stable memories correspond to stable connectivity patterns. However, an increasing body of experimental evidence points to significant, activity-independent fluctuations in synaptic strengths. How memories can survive these fluctuations and the accompanying stabilizing homeostatic mechanisms is a fundamental open question. Here we explore the possibility of memory storage within a global component of network connectivity, while individual connections fluctuate. We find that homeostatic stabilization of fluctuations differentially affects different aspects of network connectivity. Specifically, memories stored as time-varying attractors of neural dynamics are more resilient to erosion than fixed-points. Such dynamic attractors can be learned by biologically plausible learning-rules and support associative retrieval. Our results suggest a link between the properties of learning-rules and those of network-level memory representations, and point at experimentally measurable signatures.
Keyword:
NEURAL-NETWORKS
DYNAMICS
OSCILLATIONS
PATTERNS
EMERGENCE
CHAOS
THETA
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期刊
IF:
15.7
论文数:
9.3W
被引数:
91.2W
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