.png){kind=icon}
返回
Staphylococcus aureus host interactions and adaptation
.png){kind=icon}
OA
AI
DOI：10.1038/s41579-023-00852-y.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined by the interplay between S. aureus and host. This interplay is multidimensional and evolving, exemplified by the spread of S. aureus between humans and other animal reservoirs and the lack of success in vaccine development. In this Review, we examine recent advances in understanding the S. aureus-host interactions that lead to infections. We revisit the primary role of neutrophils in controlling infection, summarizing the discovery of new immune evasion molecules and the discovery of new functions ascribed to well-known virulence factors. We explore the intriguing intersection of bacterial and host metabolism, where crosstalk in both directions can influence immune responses and infection outcomes. This Review also assesses the surprising genomic plasticity of S. aureus, its dualism as a multi-mammalian species commensal and opportunistic pathogen and our developing understanding of the roles of other bacteria in shaping S. aureus colonization. In this Review, Howden and co-workers examine and integrate recent key advances in understanding the mechanisms that Staphylococcus aureus uses to cause infections.
Keyword:
SMALL-COLONY VARIANTS
IMMUNE-EVASION
EVOLUTIONARY GENOMICS
SUPPRESSOR-CELLS
PROTEIN-A
RESISTANCE
VIRULENCE
BACTEREMIA
PERSISTENT
PATHOGENICITY
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
N
IF:
103.3
论文数:
3.6K
被引数:
6.1W
机构
引用论文
分享收藏分享收藏Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial.png)
NATURE MEDICINE
OAAI
NATURE MEDICINEIF50
OAAI分享收藏
查看更多内容