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Statistical primer: sample size considerations for developing and validating clinical prediction models

delete2025-04-25
delete0
PRE
AI
G
Glen P. Martin
R
Richard D Riley
J
Joie Ensor
S
Stuart W Grant *
DOI：10.1093/ejcts/ezaf142delete
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摘要

摘要

En 中文
临床预测模型是统计模型或机器学习算法，通过结合关于个体的预测变量集的信息，来估计其特定临床结局的风险。确保用于开发或验证临床预测模型的样本量足够大至关重要。如果数据不足，开发的模型可能不稳定，且预测性能的估计会不精确。这可能导致模型不适合甚至有害于临床实践。近年来，已开发一系列样本量公式，用于估计预测模型开发或外部验证所需的最小样本量。本统计入门旨在概述这些标准，描述进行计算所需的信息，并通过实例说明其应用。文中回顾了可用于实现样本量标准的软件，并为所有实例提供了代码。临床预测模型（CPMs）是统计模型或机器学习算法，通过结合关于个体的预测变量集的信息，来估计其特定临床结局的风险或预期值[1, 2]。
Keyword:
Risk prediction
Sample size
Development
Validation
Overfitting
Evaluation

期刊

E
European Journal of Cardio-Thoracic Surgery
IF:
3
论文数:
1.5W
被引数:
1.7W

机构

U
Univ Manchester
学者数:
2.7K
论文数: 1.5K
被引数: 661
N
nihr
学者数:
37
论文数: 25
被引数: 3
引用论文

引用论文

Minimum sample size for developing a multivariable prediction model: Part I – Continuous outcomes
errStatistics in Medicine
IF0
err2018-10-22
err0
PREAI
errRichard D. Riley; Kym I.E. Snell; Joie Ensor; Danielle L. Burke; Frank E. Harrell; Karel G.M. Moons; Gary S. Collins
err分享
err收藏
External validation of clinical prediction models: simulation-based sample size calculations were more reliable than rules-of-thumb
errJOURNAL OF CLINICAL EPIDEMIOLOGY
IF5.2
err2021-07-01
err60
errOAAI
errSnell, Kym I. E.; Archer, Lucinda; Ensor, Joie; Bonnett, Laura J.; Debray, Thomas P. A.; Phillips, Bob; Collins, Gary S.; Riley, Richard D.
err分享
err收藏
Predictive value of statistical models
errStatistics in Medicine
IF0
err2006-10-12
err0
PREAI
errJ. C. Van Houwelingen; S. Le Cessie
err分享
err收藏
Targeted validation: validating clinical prediction models in their intended population and setting针对性验证: 在预期人群和环境中验证临床预测模型
errDiagnostic and Prognostic Research
IF0
err2022-12-22
err0
errOAAI
errMatthew Sperrin; Richard D. Riley; Gary S. Collins; Glen P. Martin
err分享
err收藏
Application of Shrinkage Techniques in Logistic Regression Analysis: A Case Study
errStatistica Neerlandica
IF0
err2001-12-21
err0
PREAI
errE. W. Steyerberg; M. J. C. Eijkemans; J. D. F. Habbema
err分享
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The logistic EuroSCORE
errEUROPEAN HEART JOURNAL
IF35.6
err2003-05-01
err951
errOAAI
errRoques, F; Michel, P; Goldstone, AR; Nashef, SAM
err分享
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External validation of six existing multivariable clinical prediction models for short-term mortality in patients undergoing lung resection
errEUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
IF3
err2020-11-24
err24
errOAAI
errTaylor, Marcus; Szafron, Bartlomiej; Martin, Glen P.; Abah, Udo; Smith, Matthew; Shackcloth, Michael; Granato, Felice; Shah, Rajesh; Grant, Stuart W.
err分享
err收藏
Evaluation of clinical prediction models (part 2): how to undertake an external validation study临床预测模型的评估 (第二部分): 如何进行外部验证研究
errBMJ-BRITISH MEDICAL JOURNAL
IF42.7
err2024-01-15
err33
errOAAI
errRiley, Richard; Archer, Lucinda; Snell, Kym I. E.; Ensor, Joie; Dhiman, Paula; Martin, Glen P.; Bonnett, Laura J.; Collins, Gary S.
err分享
err收藏
Statistical Primer: developing and validating a risk prediction model
errEUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
IF3
err2018-05-07
err156
errOAAI
errGrant, Stuart W.; Collins, Gary S.; Nashef, Samer A. M.
err分享
err收藏
PROBAST: A Tool to Assess Risk of Bias and Applicability of Prediction Model Studies: Explanation and ElaborationPROBAST: 一种评估偏差风险和预测模型研究适用性的工具: 解释和阐述
errANNALS OF INTERNAL MEDICINE
IF15.2
err2019-01-01
err784
errOAAI
errMoons, Karel G. M.; Wolff, Robert F.; Riley, Richard D.; Whiting, Penny F.; Westwood, Marie; Collins, Gary S.; Reitsma, Johannes B.; Kleijnen, Jos; Mallett, Sue
err分享
err收藏
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