.png){kind=icon}
.png){kind=icon}
Return
Striatal endocannabinoids drive one-shot learning
.png){kind=icon}
OA
AI
C
A
S
J
N
H
J
L
DOI：10.1038/s41593-026-02392-z.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
One-shot learning—the ability to form memories after a single, brief salient event—is essential for behavioral flexibility in a dynamic world. However, how one-shot learning unfolds in the brain and whether it relies on distinct plasticity mechanisms remains unknown. Here we show that a nonclassical plasticity mechanism requiring only a few stimulations—endocannabinoid-mediated long-term potentiation (eCB-LTP)—underlies one-shot learning in the striatum. To do so, we developed a one-shot behavioral paradigm—the sticky tape avoidance test—in which mice learn to avoid a piece of sticky tape after a spontaneous single and brief contact. Brief, but not prolonged, contacts drive striatal potentiation in vivo and engage coordinated cortical–striatal activity patterns consistent with eCB-LTP induction, as corroborated by ex vivo electrophysiology and computational modeling. Finally, genetic and pharmacological disruptions of eCB-LTP impaired one-shot learning. These results highlight the essential role of nonclassical plasticity mechanisms in supporting memory formation after a single experience. Endocannabinoid-dependent corticostriatal plasticity underlies avoidance learning in mice after a single experience. Disrupting this process impairs learning, revealing a nonclassical synaptic basis supporting one-shot learning.
Journal
IF:
20
Papers:
570
Citations:
7.1W
Organization
Cited Papers