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Striatal Tau Pathology Underlies Monoaminergic Disruption in Progressive Supranuclear Palsy

delete2026-07-06
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OA
AI
C
Chong Dong *
J
Jinghong Ma *
Q
Qiao, Hong-Wen PhD†
W
Wenqi Xu
G
Gu, Zhu-Qin MD‡
O
Olivier Barret
T
Tamagnan, Gilles D. PhD‡, ∥
M
Mao, Wei MD *
X
Xu, Er-He MD *
Z
Zhang, Chun MD†
卢
卢杰 (Jie Lu)
P
Piu Chan *
刘树迎 cover
刘树迎 (Shuying Liu) *
DOI：10.1097/RLU.0000000000006594delete
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Abstract

Abstract

En 中文
Progressive supranuclear palsy (PSP) is a tauopathy marked by widespread tau aggregation and prominent monoaminergic dysfunction, yet the relationship between regional tau burden and monoaminergic impairment remains unclear. In this study, we determine whether regional tau burden is associated with nigrostriatal monoaminergic dysfunction in PSP using PET imaging.
Keywords:
progressive supranuclear palsy
tauopathy
pathology
nigrostriatal system
multimodal PET

Journal

Clinical Nuclear Medicine cover
Clinical Nuclear Medicine
IF:
9.6
Papers:
1.1W
Citations:
6.9K

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