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Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P
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DOI：10.1016/j.tins.2026.06.007.png)
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Abstract
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Basal ganglia–cortical interactions are critical for goal-directed behavior. Sun et al . recently demonstrated a novel mechanism by which the striatum may impact the cortex via basal forebrain cholinergic neurons. These neurons are activated by D1 dopamine receptor-regulated striatal output through substance P release, which may increase arousal and attention and modulate other functions.
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