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Structural analysis and anti-alcoholic liver disease effects of a polysaccharide from Arundo donax L. rhizome
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DOI：10.1016/j.phymed.2026.158686.png)
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Abstract
En 中文
• A novel polysaccharide (ADLP) was isolated from the rhizome of Arundo donax L. • The structural characteristics of ADLP were characterized. • ADLP was demonstrated to alleviate alcoholic liver injury. • ADLP exerts hepatoprotective effects by promoting hepatic lipid metabolism. • ADLP exerts hepatoprotective effects via the gut–liver axis.
Keywords:
Arundo donax L.
Alcoholic liver disease
Polysaccharide
Gut-liver axis
ADLP
,
Arundo donax L. rhizomes polysaccharides
ALD
,
Alcoholic liver disease
ALT
,
Alanine aminotransferase
AMPK
,
AMP-activated protein kinase
AST
,
Aspartate aminotransferase
CHO
,
Cholesterol
FT-IR
,
Fourier transform infrared spectroscopy
GPC
,
Gel permeation chromatography
HE staining
,
Hematoxylin-eosin staining
IHC
,
Immunohistochemical
LPS
,
Lipopolysaccharide
MDI
,
Microbial dysbiosis index
MHI
,
Microbiome health index
Mn
,
Number-average molecular weight
Mw
,
Weight-average molecular weight
NMDS
,
Non-metric multidimensional scaling analyses
NMR
,
Nuclear magnetic resonance
OTUs
,
Operational taxonomic units
PCA
,
Principal component analysis
PCoA
,
Principal co-ordinates analysis
PPARa
,
Peroxisome proliferator-activated receptor a
PPAR?
,
Peroxisome proliferator-activated receptor ?
SCFAs
,
Short-chain fatty acids
SEM
,
SCANNING electron microscopy
TBA
,
Total bile acids
TG
,
Triglycerides
ZO-1
,
Zonula occludens-1
Journal
IF:
8.3
Papers:
9.0K
Citations:
3.1W
Organization
Cited Papers