Structural Insights into Polyhydroxyalkanoates Biosynthesis

doi:10.1016/j.tibs.2018.08.005

2018-10-01

PRE

Hye-Young Sagong

Hyeoncheol Francis Son

So Young Choi

Sang Yup Lee *

Kyung‐Jin Kim *

DOI：10.1016/j.tibs.2018.08.005

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摘要

En 中文

Polyhydroxyalkanoates (PHAs) are diverse biopolyesters produced by numerous microorganisms and have attracted much attention as a substitute for petroleum-based polymers. Despite several decades of study, the detailed molecular mechanisms of PHA biosynthesis have remained unknown due to the lack of structural information on the key PHA biosynthetic enzyme PHA synthase. The recently determined crystal structure of PHA synthase, together with the structures of acetyl-coenzyme A (CoA) acetyltransferase and reductase, have changed this situation. Structural and biochemical studies provided important clues for the molecular mechanisms of each enzyme as well as the overall mechanism of PHA biosynthesis from acetyl-CoA. This new information and knowledge is expected to facilitate production of designed novel PHAs and also enhanced production of PHAs.

Keyword:

RALSTONIA-EUTROPHA H16

TRANSMISSION ELECTRON-MICROSCOPY

GRANULE-ASSOCIATED PROTEINS

ALCALIGENES-EUTROPHUS

CRYSTAL-STRUCTURE

POLYHYDROXYBUTYRATE SYNTHASE

PSEUDOMONAS-AERUGINOSA

ESCHERICHIA-COLI

PHA SYNTHASE

BACILLUS-MEGATERIUM

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期刊

Trends in Biochemical Sciences

IF:

论文数:

6.6K

被引数:

2.0W

机构

kyungpook national university (knu)

学者数:

1.8W

论文数: 1.8W

被引数: 14

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