Structural MRI Volumetry Index for Differentiation of Progressive Supranuclear Palsy From Parkinson's Disease and Multiple System Atrophy by Automatic Segmentation: A Comparison With Magnetic Resonance Parkinsonism Index

2026-07-01

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Mingnan Jia

Hui You

Zhaoxi Liu

Yichun Wang

Han Wang *

Mingli Li

Feng Feng *

DOI：10.1002/jmri.70418

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Although Parkinson's disease (PD) and Parkinsonism-Plus syndromes (PPS) exhibit distinct brain atrophy, current clinical differentiation heavily relies on manual, plane-specific 2D metrics, which are labor-intensive and observer-dependent. To fill this gap, this study developed an automated, software-independent metric—the parkinsonism volumetric index (PDSVI)—calculated as [(pons volume × third ventricle volume)/(midbrain volume × thalamus volume) × 10].

Keywords:

automated segmentation

MRI biomarker

multiple system atrophy

Parkinson's disease

progressive supranuclear palsy

Structural MRI Volumetry Index for Differentiation of Progressive Supranuclear Palsy From Parkinson's Disease and Multiple System Atrophy by Automatic Segmentation: A Comparison With Magnetic Resonance Parkinsonism Index

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