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Structure-based DNA Memory with Boolean Random Access

delete2025-10-06
delete0
PRE
AI
Y
Yanyu Zhou
L
Lanyang Gao
J
Jiang Chu
Y
Yuxi Li
Q
Qi Liu
C
Chengguo Xu
Y
Yingying Liu
H
Huajie Liu
张
张轶楠 (Yinan Zhang)
DOI：10.1039/D5NH00502Gdelete
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Abstract

Abstract

En 中文
Structure-based DNA memory represents a paradigm shift from nucleotide-encoded storage; circumventing the costly repetitive synthesis and sequencing dependencies while harnessing the programmable architecture of DNA nanostructures. However; the absence of random-access capability has constrained practical implementation. Here; we implement a Boolean search-enabled random-access scheme for structural DNA memory; wherein data is encoded on DNA origami tiles with orthogonally dimensioned index strands (1D/2D/3D addressing). Boolean operations are executed by hybridizing biotinylated probes to target index combinations; enabling the magnetic extraction of specific files. Atomic force microscopy validation confirms the precise retrieval of data across single-; dual-; and triple-indexed libraries. This approach establishes a robust framework for enabling random access in complex structural DNA databases.

Journal

Nanoscale Horizons cover
Nanoscale Horizons
IF:
6.6
Papers:
1.3K
Citations:
6.3K

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No organization information available