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Studies of vitamin A metabolism in mouse model systems
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DOI：10.1002/bies.1059.png)
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Abstract
En 中文
Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the metabolism of vitamin A through a number of genetically engineered mouse strains with alterations in genes that affect this metabolism. The novelty of this experimental approach is evidenced by the fact that the oldest of these strains was first reported only eight years ago.((1)) (C) 2001 John Wiley & Sons, Inc.
Keywords:
RETINOID-BINDING PROTEIN
INTERPHOTORECEPTOR MATRIX
ALDEHYDE DEHYDROGENASE
PIGMENT-EPITHELIUM
EARLY EXPRESSION
GENE-EXPRESSION
TRANSGENIC MICE
CARBOXYL ESTER
PLASMA RETINOL
VISUAL CYCLE
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