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Subcellular Imbalances in Synaptic Activity
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DOI：10.1016/j.celrep.2016.01.024.png)
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The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local synaptic excitation and global inhibition in hippocampal pyramidal neurons using functional dendrite imaging in combination with whole-cell recordings of inhibitory postsynaptic currents. We found that the sums of spine inputs over dendritic trees were counterbalanced by a proportional amount of somatic inhibitory inputs. This online E/I correlation was maintained in dendritic segments that were longer than 50 mu m. However, at the single spine level, only 22% of the active spines were activated with inhibitory inputs. This inhibition-coupled activity occurred mainly in the spines with large heads. These results shed light on a microscopic E/I-balancing mechanism that operates at selected synapses and that may increase the accuracy of neural information.
Keyword:
CORTICAL-NEURONS
INHIBITION
EXCITATION
NETWORKS
FIDELITY
BALANCE
SPINES
CORTEX
VIVO
期刊
IF:
6.9
论文数:
1.7W
被引数:
10.2W
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引用论文
Space matters:: local and global dendritic Ca2+ compartmentalization in cortical interneurons.png)
TRENDS IN NEUROSCIENCES
TRENDS IN NEUROSCIENCESIF15.1
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