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Subcritical CO₂-Expanded Nanofibrous Scaffold Reinforced with Alginate-Collagen Gel for Controlled Drug Release in Tissue Regeneration
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DOI：10.1016/j.supflu.2025.106765.png)
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Abstract
En 中文
● Subcritical CO₂-expanded scaffolds enable sustained Lawsone release in burn wounds ● Porous nanofibrous architecture (SEM) promotes fluid exchange and cell infiltration ● Antioxidant-loaded scaffolds mitigate oxidative stress and regulate inflammation (IL-6, IL-10, CXN-43, SphK1) ● Enhanced fibroblast proliferation and ECM remodelling improve regenerative outcomes ● Cross-linked collagen matrix provides mechanical strength and enzymatic resilience
Keywords:
Lawsone release
porous nanofibrous architecture
antioxidant-loaded scaffolds
fibroblast proliferation
collagen matrix
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