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Subspace partitioning in the human prefrontal cortex resolves cognitive interference
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DOI：10.1073/pnas.2220523120.png)
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摘要
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The human prefrontal cortex (PFC) constitutes the structural basis underlying flexi-ble cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. The mechanisms by which the brain simulta-neously encodes multiple task-relevant variables while minimizing interference from task-irrelevant features remain unknown. Leveraging intracranial recordings from the human PFC, we first demonstrate that competition between coexisting representations of past and present task variables incurs a behavioral switch cost. Our results reveal that this interference between past and present states in the PFC is resolved through coding partitioning into distinct low-dimensional neural states; thereby strongly attenuating behavioral switch costs. In sum, these findings uncover a fundamental coding mechanism that constitutes a central building block of flexible cognitive control.
Keyword:
prefrontal cortex
intracranial EEG
cognitive control
population geometry
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论文数:
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被引数:
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