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Subventricular Zone Microstructure in Pediatric-Onset Multiple Sclerosis
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DOI：10.1002/ana.27180.png)
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Objective: The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric-onset multiple sclerosis (MS) patients. Methods: One-hundred and forty-one pediatric-onset MS patients (67 pediatric and 74 adults with pediatric-onset) and 233 healthy controls (HC) underwent neurological and 3.0 T MRI assessment. Fractional anisotropy (FA) and mean diffusivity (MD) were extracted from the SVZ and the thalamus (as control region). Results: In HC, SVZ FA was higher until age 40 then declined, whereas MD was lower until age 35 before rising (false discovery rate p value [pFDR] <= 0.008). Thalamic FA was higher until age 30 and then declined, whereas MD was higher until age 50 (pFDR <= 0.007). Pediatric MS patients showed significantly higher SVZ FA than pediatric HC (pFDR < 0.001), while adult patients showed no differences compared to adult HC (pFDR <= 0.724). Adult patients had lower thalamic FA and higher MD (pFDR < 0.001). Adults had lower SVZ FA and MD, but higher thalamic MD compared to pediatric patients (pFDR < 0.001). In pediatric MS, higher SVZ FA and MD were associated with higher white matter (WM) lesion volume (LV) and choroid plexus volume and lower brain and thalamic volumes (pFDR <= 0.047). In adult patients, higher SVZ MD associated with higher WM LV, lower brain volumes, and lower z-SDMT (pFDR <= 0.019). Thalamic microstructural abnormalities were associated with more severe disability and brain damage in both groups (pFDR <= 0.018). Interpretation: Our findings suggest that microstructural changes in the SVZ occur early in pediatric MS and are associated with brain structural damage but not with clinical impairment. ANN NEUROL 2025
Keyword:
NEURAL STEM-CELLS
HUMAN BRAIN
COGNITIVE IMPAIRMENT
CHILDHOOD
NEURONS
PROLIFERATION
REMYELINATION
NEUROGENESIS
INFLAMMATION
PROGENITORS
期刊
IF:
7.7
论文数:
8.5K
被引数:
3.6W
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