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Success and failure with the antidyskinetic effect of Globus Pallidus Internus Deep Brain Stimulation: A sweetspot and connectivity analysis in the CSP-468 Cohort
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DOI：10.1016/j.neurom.2026.06.462.png)
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Abstract
En 中文
Deep brain stimulation (DBS) of the globus pallidus internus (GPi) can reduce levodopa-induced dyskinesias, yet GPi targeting sometimes fails or worsens them, suggesting distinct prokinetic/antikinetic circuit mechanisms. Using the broad GP sampling from the CSP-468 trial, we sought to identify stimulation zones and connectivity maps that predict dyskinesia outcomes in GPi-DBS patients.
Keywords:
Parkinson’s Disease
Deep Brain Stimulation
Globus Pallidus Interna
Dyskinesias
Ansa Lenticularis
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