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Sugar rationing during the first 1000 days and Early-Onset Cancer: A Natural Experiment
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DOI：10.1016/j.ajcnut.2026.101453.png)
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Abstract
En 中文
The “First 1000 Days” of life is a critical window for metabolic programming, while the long-term oncological consequences of nutritional exposures during this period remain understudied. We aimed to evaluate whether restricted sugar intake in utero and during early childhood reduces the risk of early-onset cancer diagnosis and mortality in adulthood, utilizing a natural experiment.
Keywords:
Sugar Exposure
First 1000 Days
Early-Onset Cancer
Quasi-experimental Design
Disease-Free Lifespan
CI
Confidence Interval
CSS
Cancer-Specific Survival
FDR
False Discovery Rate
HR
Hazard Ratio
ICD-10
International Classification of Diseases, 10th Revision
NFS
National Food Survey
NHS
National Health Service
OS
Overall Survival
RDD
Regression Discontinuity Design
SD
Standard Deviation
UKBB
UK Biobank
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