Super-Resolution Microscopy in Tissue Engineering

Navid Rabiee

doi:10.1002/admi.202500437

2025-09-04

Navid Rabiee *

Mohammad Akrami‐Hasan‐Kohal

Sidi A. Bencherif *

DOI：10.1002/admi.202500437

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摘要

En 中文

组织工程旨在通过支架、细胞和生物分子来修复或替换受损器官。一个关键挑战仍然存在：在工程环境中可视化复杂的细胞和分子相互作用。传统成像方法难以捕捉理解干细胞行为、组织形成和细胞-支架相互作用所必需的纳米级细节。超分辨率显微镜（SRM）提供了一种解决方案，通过实现超越衍射极限的成像，揭示组织工程中涉及的临界纳米级过程。SRM为细胞粘附、迁移和分化提供了宝贵的见解，并通过可视化细胞组分的组织及其与细胞外基质的关系，促进了支架设计的优化。通过将SRM整合到临床前研究中，研究人员可以改进组织工程构建体的评估和发展，弥合基础研究与临床应用之间的差距。总体而言，SRM通过揭示驱动功能性组织整合的先前无法获取的细节，为加速器官再生领域的进展带来了巨大潜力。

Keyword:

nanoscale mapping

organ regeneration

super-resolution microscopy

tissue engineering

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期刊

Advanced Materials Interfaces

IF:

4.4

论文数:

6.7K

被引数:

2.4W

机构

University of Rouen Normandy

学者数:

论文数: 18

被引数: 0

Saveetha University

学者数:

776

论文数: 687

被引数: 1.1W

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