.png){kind=icon}
返回
Suprapontine Structures Modulate Brainstem and Spinal Networks
.png){kind=icon}
OA
AI
DOI：10.1007/s10571-023-01321-z.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Several spinal motor output and essential rhythmic behaviors are controlled by supraspinal structures, although their contribution to neuronal networks for respiration and locomotion at birth still requires better characterization. As preparations of isolated brainstem and spinal networks only focus on local circuitry, we introduced the in vitro central nervous system (CNS) from neonatal rodents to simultaneously record a stable respiratory rhythm from both cervical and lumbar ventral roots (VRs). Electrical pulses supplied to multiple sites of brainstem evoked distinct VR responses with staggered onset in the rostrocaudal direction. Stimulation of ventrolateral medulla (VLM) resulted in higher events from homolateral VRs. Stimulating a lumbar dorsal root (DR) elicited responses even from cervical VRs, albeit small and delayed, confirming functional ascending pathways. Oximetric assessments detected optimal oxygen levels on brainstem and cortical surfaces, and histological analysis of internal brain structures indicated preserved neuron viability without astrogliosis. Serial ablations showed precollicular decerebration reducing respiratory burst duration and frequency and diminishing the area of lumbar DR and VR potentials elicited by DR stimulation, while pontobulbar transection increased the frequency and duration of respiratory bursts. Keeping legs attached allows for expressing a respiratory rhythm during hindlimb stimulation. Trains of pulses evoked episodes of fictive locomotion (FL) when delivered to VLM or to a DR, the latter with a slightly better FL than in isolated cords. In summary, suprapontine centers regulate spontaneous respiratory rhythms, as well as electrically evoked reflexes and spinal network activity. The current approach contributes to clarifying modulatory brain influences on the brainstem and spinal microcircuits during development.
Keyword:
Motor-evoked potentials
Fictive respiration
Fictive locomotion
Decerebration
Leg attached
Isolated central nervous system
Tissue oxygenation
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.8
论文数:
3.4K
被引数:
7.3K
机构
引用论文
Non-CRET-Based Green Chemiluminescence of Imidazopyrazinone Modified by 2,3,6,7-Tetrahydro-1H,5H-benzo[i,j]quinolizine as a Strong Electron-Donating Unit基于非CRET的咪唑并吡嗪酮经2,3,6,7-四氢-1H,5H-苯并[i,j]喹啉二酮修饰的绿色化学发光，作为强电子供体单元.png)
HETEROCYCLES
OAAI
HETEROCYCLESIF0
OAAI分享收藏Humanized Chronic Graft-versus-Host Disease in NOD-SCID il2rγ-/- (NSG) Mice with G-CSF-Mobilized Peripheral Blood Mononuclear Cells following Cyclophosphamide and Total Body IrradiationPLOS ONEOAAI
PLOS ONEIF0
OAAI分享收藏Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient miceMOLECULAR BRAINOAAI
MOLECULAR BRAINIF2.9
OAAI分享收藏
查看更多内容