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Synaptic tagging during memory allocation
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DOI：10.1038/nrn3667.png)
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There is now compelling evidence that the allocation of memory to specific neurons (neuronal allocation) and synapses (synaptic allocation) in a neurocircuit is not random and that instead specific mechanisms, such as increases in neuronal excitability and synaptic tagging and capture, determine the exact sites where memories are stored. We propose an integrated view of these processes, such that neuronal allocation, synaptic tagging and capture, spine clustering and metaplasticity reflect related aspects of memory allocation mechanisms. Importantly, the properties of these mechanisms suggest a set of rules that profoundly affect how memories are stored and recalled.
Keyword:
LONG-TERM POTENTIATION
ELEMENT-BINDING PROTEIN
CA1 PYRAMIDAL NEURONS
IN-VIVO
ALZHEIMERS-DISEASE
DENDRITIC SPINES
SPATIAL MEMORY
HIPPOCAMPAL SLICES
DECLARATIVE MEMORY
AMYGDALA NEURONS
期刊
IF:
26.7
论文数:
4.0K
被引数:
4.8W
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