Synthesis of benzoyloxynaphthalene derivatives by O-alkylation via calcined red algae doped by KOH (KOH@CRA) as green heterogeneous catalyst: tubulin activity investigation

Ghizlane Lahlalate

doi:10.1016/j.inoche.2026.117323

Synthesis of benzoyloxynaphthalene derivatives by O-alkylation via calcined red algae doped by KOH (KOH@CRA) as green heterogeneous catalyst: tubulin activity investigation

2026-08-02

0

PRE

AI

G

Ghizlane Lahlalate

A

Ali Barazzouq

M

Mouna Azogagh

F

Fatima Zahra Zamzami

L

Lahoucine Bahsis

N

Noura Aflak

Y

Youssef Edder

M

Mohammed Daoudi

L

Layachi Khamliche

D

Driss Ouzebla

R

Rachid Hsissou *

DOI：10.1016/j.inoche.2026.117323

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• KOH@CRA ecofriendly catalyst elaborated before and after application was characterized by BET, XRD, FTIR, and SEM/EDS techniques. • Benzoyloxynaphthalene derivatives synthetized via KOH@CRA as green heterogenous catalyst were characterized by FTIR, NMR, and mass spectrometry. • KOH@CRA catalyst was reused several times without significant deterioration of their catalytic performance. • Synthetized compounds (2a, 2b, 2c, 2d, and 2e) exhibited significantly higher binding energies compared to the antiviral drug tubulin activity.

Synthesis of benzoyloxynaphthalene derivatives by O-alkylation via calcined red algae doped by KOH (KOH@CRA) as green heterogeneous catalyst: tubulin activity investigation

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