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α-Synuclein in Parkinson's disease and advances in detection
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DOI：10.1016/j.cca.2022.02.006.png)
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Abstract
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Parkinson's disease (PD) is a threatening neurodegenerative disorder that seriously affects patients' life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (alpha-Syn) to PD. alpha-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic process of alpha-Syn based on recent researches, outlines and compares commonly used analysis and detection technologies of alpha-Syn. Specifically, the detection of alpha-Syn by new electrochemical, photochemical, and crystal biosensors is mainly examined. Furthermore, the speculation of future study orientation is discussed, which provides reference for the further research and application of alpha-Syn as biomarker.
Keywords:
Alpha-synuclein
Parkinson's disease
Pathogenic process
Detection method
Biosensor
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2.9
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1.5W
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2.1W
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