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Syzydyerin A, a new unusual C-methylated chalcone isolated from the leaves of Syzygium dyerianum (King) Chantar. & J.Parn
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DOI：10.1515/znc-2025-0179.png)
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Abstract
En 中文
A new unusual C-methylated chalcone was successfully isolated from the leaves of Syzygium dyerianum (King) Chantaran. & J.Parn, identified as syzydyerin A (1), together with beta-sitosterol, friedelin and lupeol. The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. Compound 1 exhibited inhibitory activity against acetylcholinesterase (AChE) and lipoxygenase (LOX) with IC50 values of 50.4 +/- 0.2 mu m and 30.7 +/- 0.25 mu m, respectively, compared to the reference inhibitors galantamine (IC50 = 40.7 +/- 0.12 mu m) for AChE and quercetin (IC50 = 3.5 +/- 0.13 mu m) 5-LOX. Molecular docking analysis revealed that compound 1 exhibits strong binding affinities toward AChE (-11.0 kcal/mol) and 5-LOX (-9.1 kcal/mol), comparable to standard inhibitors, with key pi-pi stacking and hydrogen bonding interactions stabilizing its binding at both active sites, highlighting its promising dual inhibitory potential. The study underscores the value of S. dyerianum as a source of bioactive compounds with potential applications in treating neuroinflammatory diseases.
Keywords:
myrtaceae
Syzygium dyerianum
c-methylation
chalcone
acetylcholinesterase
lipoxygenase
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Z
IF:
2.1
Papers:
27
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0
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