T Cells Dysfunction in Multiple Myeloma

Linyu Cai

doi:10.2147/ITT.S534784

2025-09-11

DOI：10.2147/ITT.S534784

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摘要

En 中文

多发性骨髓瘤（MM）是一种浆细胞血液系统恶性肿瘤。由于抗CD38单克隆抗体、嵌合抗原受体T细胞（CAR-T）和双特异性T细胞衔接器（TCEs）的临床应用，患者生存率取得了显著进展。然而，骨髓的免疫抑制微环境阻碍了这些新型免疫疗法的效果，从而限制了其疗效。因此，阐明确切机制以制定旨在提高免疫疗法疗效的策略至关重要。在本综述中，我们提供了关于MM免疫逃逸机制中不同T细胞亚型最新研究的系统概述。该综述强调了免疫监视与免疫抑制之间的失衡，并重点介绍了关于非传统T细胞、免疫反应的代谢调控以及针对促进MM进展的免疫逃逸机制的新型治疗策略的最新研究。

Keyword:

multiple myeloma

immune escape

immunosuppressive cells

Th17

CTL

Treg

期刊

ImmunoTargets and Therapy

IF:

4.4

论文数:

283

被引数:

894

机构

institute of hematology

学者数:

论文数: 24

被引数: 0

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