.png){kind=icon}
返回
.png){kind=icon}
.png){kind=icon}
摘要
En 中文
We study the target control of asynchronous Boolean networks, to identify interventions that can drive the dynamics of a given Boolean network from any initial state to the desired target attractor. Based on the application time, the control can be realised with three types of perturbations, including instantaneous, temporary and permanent perturbations. We develop efficient methods to compute the target control for a given target attractor with these three types of perturbations. We compare our methods with the stable motif-based control method on a variety of real-life biological networks to evaluate their performance. We show that our methods scale well for large Boolean networks and they are able to identify a rich set of solutions with a small number of perturbations.
Keyword:
Boolean networks
network control
attractor
perturbations
期刊
I
IF:
3.4
论文数:
3.3K
被引数:
6.4K
机构
引用论文
.png){kind=icon}
分享.png){kind=icon}
收藏分享收藏A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis.png)
CANCER RESEARCH.png)
OAAI
CANCER RESEARCHIF16.6
OAAI分享收藏Optimal control of Boolean control networks with average cost: A policy iteration approachAUTOMATICA
AUTOMATICAIF5.9
PREAI
分享收藏
查看更多内容