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Targeted polymeric nanoparticles enable epithelial translocation of PROTACs and preserve intracellular protein degradation activity
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DOI：10.1016/j.ejps.2026.107587.png)
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Abstract
En 中文
• First targeted nanoparticle strategy to enhance PROTAC intestinal transport. • Antibody-functionalization significantly enhances epithelial translocation. • Encapsulation preserves PROTAC pharmacodynamic activity in target cells.
Keywords:
PROTAC
nanoparticles
antibody targeting
epithelial permeation
protein degradation
nanomedicine
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