Targeted Proteomics for Studying Pathogenic Bacteria

S Saleh

doi:10.1002/pmic.201800435

2019-07-25

PRE

DOI：10.1002/pmic.201800435

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摘要

En 中文

Mass spectrometry-based proteomics has been extensively used to map bacterial proteomes, which has led to a better understanding of the molecular mechanisms underlying bacterial infection and bacteria-host interactions. Quantitative proteomics using selected or parallel reaction monitoring is considered one of the most sensitive and specific quantitative MS-based approaches and has significantly advanced proteome studies of pathogenic bacteria. Here, recent applications of targeted proteomics for bacteria identification, biomarker discovery, and the characterization of bacterial virulence and antimicrobial resistance are reviewed among others. Results of such studies are expected to further contribute to improve the fight against the most common human pathogenic bacteria.

Keyword:

antibiotic resistance

bacteria

biomarkers

targeted proteomics

virulence

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期刊

Proteomics

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3.9

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7.6K

被引数:

1.1W

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VIB

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7.8K

论文数: 5.2K

被引数: 18

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