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Targeted selenium nanoparticles alleviate osteoarthritis by suppressing ROS-driven chondrocyte inflammation

delete2026-07-28
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PRE
AI
M
Mingda Zhao
Z
Zhulian Li
J
Jiadong Li
X
Xinyu Zhang
X
Xing Li
Y
Yani Cui *
Y
Yujiang Fan
Y
Yong Sun *
DOI：10.1016/j.nantod.2026.103132delete
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Abstract

Abstract

En 中文
• HSe NPs with hyaluronan enhance stability and CD44-targeted delivery to inflammatory chondrocytes. • HSe NPs upregulate GPX1 to scavenge ROS, suppress chondrocyte inflammation and reducing secretion of CCL2, CXCL1 and IL-6 secretion. • HSe NPs promote M2 macrophage polarization, suppress joint inflammation and alleviating osteoarthritis progression.

Journal

Nano Today cover
Nano Today
IF:
10.9
Papers:
3.0K
Citations:
2.1W

Organization

S
sichuan university
Scholars:
11.5W
Papers: 7.6W
Citations: 100
N
naval medical university
Scholars:
4.7K
Papers: 1.4K
Citations: 175
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