Targeting DDAH II with Puerarin ameliorates doxorubicin-induced endothelial damage and ferroptosis through ADMA/NOS dysregulation rescue

2026-08-07

Lewei Guan

Xuanzhi Cheng

胡亦辰 (Yichen Hu)

Jiyi Huang

Zeyu Zhang

Bei Wu

Min He

Tingxuan Liu

Xiaoping Peng *

何欢 (Huan He) *

DOI：10.1016/j.jare.2026.08.013

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• Pue-pre protects the vascular endothelium and alleviates DIE damage-induced ferroptosis. • Pue targets binding to DDAHⅡ and regulates ADMA/eNOS/NO pathway. • Pue-pre activates adaptive autophagy, attenuates Fe2+ level, oxidative stress and abnormal lipid metabolism. • Pue-pre improves energy metabolism and prevents mitochondrial dysfunction. • Pue provides dual protection against DIE damage.

Keywords:

Doxorubicin-induced endotheliotoxicity

Dimethylarginine dimethylaminohydrolase 2

Ferroptosis

Molecular targeted therapy

Puerarin

Targeting DDAH II with Puerarin ameliorates doxorubicin-induced endothelial damage and ferroptosis through ADMA/NOS dysregulation rescue

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