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Targeting JAK/STAT signalling with cold atmospheric plasma: a potential therapy for systemic lupus erythematosus
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DOI：10.1017/erm.2026.10042.png)
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Abstract
En 中文
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous multi-organ manifestations and poorly understood pathogenesis. The variable therapeutic outcomes and potential for cross-indication treatments underscore the need to identify pivotal disease-driving signalling pathways for developing innovative and safer regimens. By categorizing the pathogenesis of SLE into three interconnected stages involving over-activated immune response; skewed cytokine homeostasis and impaired debris clearance; and by analysing public clinical data; this review posits that the Janus kinase–signal transducer and activator of transcription axis is a central driver of SLE pathogenesis. Accordingly; it explores the potential of cold atmospheric plasma to modulate this pathway for therapeutic benefit that requires further experimental and clinical validations.
Keywords:
cold atmospheric plasma
Janus kinase–signal transducer and activator of transcription
Systemic lupus erythematosus
therapeutics
Journal
IF:
5.5
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76
Citations:
2.2K
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