1
Return

Targeting serotonin 5-HT2A receptors in the treatment of aggression: From antipsychotics to psychedelics

delete2026-02-10
delete0
PRE
AI
S
Simona Scheggi
G
Giulia Braccagni
C
Caterina Branca
M
Marco Bortolato *
DOI：10.1016/j.avb.2026.102139delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
• Evidence suggests 5-HT2A signaling may contribute to aggression control. • Several studies link prefrontal 5-HT2A increases with reactive aggression. • Both 5-HT2A agonists and antagonists show context-dependent anti-aggression effects. • Divergent ligand actions may reflect biased or region-specific signaling.
Keywords:
5-HT2A receptor
aggression
serotonin
antipsychotics
psychedelics

Journal

Aggression and Violent Behavior cover
Aggression and Violent Behavior
IF:
3.4
Papers:
1.7K
Citations:
6.5K

Organization

U
University of Florida
Scholars:
4.0W
Papers: 3.1W
Citations: 6.6W
U
university of siena
Scholars:
1.7K
Papers: 695
Citations: 0
Cited Papers

Cited Papers

Citing Papers

Citing Papers