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Targeting the retina-brain axis for early intervention: an observational and translational framework associating occupational stressors with probable dementia via HSP-mediated proteostasis
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DOI：10.1016/j.hazadv.2026.101442.png)
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Abstract
En 中文
• Occupational hazards (PM2.5, heat) elevate risk of probable dementia. • Retinal pathology independently predicts probable dementia in a cohort of 10,914. • Retinal health mediates the toxico-pathological axis between work environment and AD. • Bioinformatics links systemic neural proteostatic strain to HSPA4 and HSP90AA1.
Keywords:
Retina-brain axis
Occupational exposure
Probable dementia
Retinal pathology
Heat shock proteins
NHANES
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