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Task-dependent mixed selectivity in the subiculum
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DOI：10.1016/j.celrep.2021.109175.png)
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摘要
En 中文
CA1 and subiculum (SUB) connect the hippocampus to numerous output regions, Cells in both areas have place-specific firing fields, although they are more dispersed in SUB, Weak responses to head direction and running speed have been reported in both regions. However, how such information is encoded in CA1 and SUB and the resulting impact on downstream targets are poorly understood. Here, we estimate the tuning of simultaneously recorded CA1 and SUB cells to position, head direction, and speed. Individual neurons respond conjunctively to these covariates in both regions, but the degree of mixed representation is stronger in SUB, and more so during goal-directed spatial navigation than free foraging. Each navigational variable could be decoded with higher precision, from a similar number of neurons, in SUB than CA1. The findings point to a possible contribution of mixed-selective coding in SUB to efficient transmission of hippocampal representations to widespread brain regions.
Keyword:
PREFRONTAL CORTEX
HEAD-DIRECTION
SPATIAL REPRESENTATION
FIRING CHARACTERISTICS
WORKING-MEMORY
UNIT-ACTIVITY
GRID CELLS
HIPPOCAMPAL
NEURONS
PLACE
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