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Technical Note: Simultaneous segmentation and relaxometry for MRI through multitask learning
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DOI：10.1002/mp.13756.png)
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Purpose This study demonstrated a magnetic resonance (MR) signal multitask learning method for three-dimensional (3D) simultaneous segmentation and relaxometry of human brain tissues. Materials and Methods A 3D inversion-prepared balanced steady-state free precession sequence was used for acquiring in vivo multicontrast brain images. The deep neural network contained three residual blocks, and each block had 8 fully connected layers with sigmoid activation, layer norm, and 256 neurons in each layer. Online-synthesized MR signal evolutions and labels were used to train the neural network batch-by-batch. Empirically defined ranges of T1 and T2 values for the normal gray matter, white matter, and cerebrospinal fluid (CSF) were used as the prior knowledge. MRI brain experiments were performed on three healthy volunteers. The mean and standard deviation for the T1 and T2 values in vivo were reported and compared to literature values. Additional animal (N = 6) and prostate patient (N = 1) experiments were performed to compare the estimated T1 and T2 values with those from gold standard methods and to demonstrate clinical applications of the proposed method. Results In animal validation experiment, the differences/errors (mean difference +/- standard deviation of difference) between the T1 and T2 values estimated from the proposed method and the ground truth were 113 +/- 486 and 154 +/- 512 ms for T1, and 5 +/- 33 and 7 +/- 41 ms for T2, respectively. In healthy volunteer experiments (N = 3), whole brain segmentation and relaxometry were finished within ~ 5 s. The estimated apparent T1 and T2 maps were in accordance with known brain anatomy, and not affected by coil sensitivity variation. Gray matter, white matter, and CSF were successfully segmented. The deep neural network can also generate synthetic T1- and T2-weighted images. Conclusion The proposed multitask learning method can directly generate brain apparent T1 and T2 maps, as well as synthetic T1- and T2-weighted images, in conjunction with segmentation of gray matter, white matter, and CSF.
Keyword:
brain segmentation
deep neural network
gray matter
machine learning
MR fingerprinting
relaxometry
white matter
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