.png){kind=icon}
返回
Technologies for Multilayered Scaffolds Suitable for Interface Tissue Engineering
.png){kind=icon}
PRE
AI
DOI：10.1002/adem.201300072.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Multilayered scaffolds that provide tailored space-specific biological and mechanical functions are promising for interface tissue engineering such as in osteochondral tissue regeneration. In this study, fabrication techniques, including foam replication, gelation, and freeze-drying techniques, were combined in order to manufacture stratified scaffolds mimicking the layered structure of native osteochondral tissue. 45S5 Bioglass (R) and alginate were used to fabricate 3D highly porous (composite) scaffolds for the underlying subchondral bone layer. Freeze-dried alginate-based scaffolds were produced for the cartilage layer. Finally, both layers were integrated using a novel alginate/45S5 Bioglass (R) hybrid interface acting as an adhesive, which functions as the cartilage-bone interfacial layer. Novel multilayered scaffolds were optimized to achieve the complex requirements for osteochondral tissue engineering such as the 3D architecture, porous structure, physical, and mechanical properties, which are presented and discussed in the context of the intended application of the novel scaffolds in osteochondral tissue regeneration.
Keyword:
STEM-CELLS
OSTEOCHONDRAL REGENERATION
MECHANICAL-PROPERTIES
COMPOSITE SCAFFOLDS
CELLULAR SOLIDS
IN-VITRO
CARTILAGE
ALGINATE
DEFECTS
45S5
期刊
IF:
3.3
论文数:
9.3K
被引数:
2.2W
机构
引用论文
A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering一种快速固化的藻酸盐凝胶系统: 在骨膜衍生的软骨组织工程中的应用.png)
BIOMATERIALS
BIOMATERIALSIF12.9
PREAI
分享收藏How useful is SBF in predicting in vivo bone bioactivity?SBF在预测体内骨生物活性方面有多大用处？BIOMATERIALS
BIOMATERIALSIF12.9
PREAI
分享收藏Maintaining dimensions and mechanical properties of ionically crosslinked alginate hydrogel scaffolds in vitro维持离子交联藻酸盐水凝胶支架的尺寸和机械性能
OAAI
OAAI分享收藏Simple fabrication technique for multilayered stratified composite scaffolds suitable for interface tissue engineeringMATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSINGIF7
PREAI
分享收藏分享收藏分享收藏Treatment of Cancer with Radio-Immunotherapy: What We Currently Know and What the Future May Hold
OAAI
OAAI分享收藏Cell proliferation and controlled drug release studies of nanohybrids based on chitosan-g-lactic acid and montmorilloniteACTA BIOMATERIALIA
ACTA BIOMATERIALIAIF9.6
PREAI
分享收藏
查看更多内容