.png){kind=icon}
返回
Template-based prediction of protein function
.png){kind=icon}
OA
AI
DOI：10.1016/j.sbi.2015.01.007.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
We discuss recent approaches for structure-based protein function annotation. We focus on template-based methods where the function of a query protein is deduced from that of a template for which both the structure and function are known. We describe the different ways of identifying a template. These are typically based on sequence analysis but new methods based on purely structural similarity are also being developed that allow function annotation based on structural relationships that cannot be recognized by sequence. The growing number of available structures of known function, improved homology modeling techniques and new developments in the use of structure allow template-based methods to be applied on a proteome-wide scale and in many different biological contexts. This progress significantly expands the range of applicability of structural information in function annotation to a level that previously was only achievable by sequence comparison.
Keyword:
WEB SERVER
EXPERIMENTAL VALIDATION
BINDING RESIDUES
SITES
SCALE
SPECIFICITY
ANNOTATION
ALGORITHM
NETWORKS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
7
论文数:
3.8K
被引数:
1.3W
机构
引用论文
Polyhydroxylated indolizidine alkaloids—an efficient synthesis of 1-deoxy-8,8a-di-epi-castanospermine.png)
Tetrahedron
TetrahedronIF0
PREAI
分享收藏
分享收藏
查看更多内容