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Temporal multi-omic analysis uncovers sex-biased molecular programs underlying skeletal muscle adaptation to endurance training

delete2026-08-12
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OA
AI
G
Gina M. Many
C
Christopher Jin
N
Nicholas J. Day
G
Gayatri Iyer
G
Gregory Smith
K
Kayleigh Voos
J
James A. Sanford
A
Akshay Bareja
D
David Jimenez-Morales
D
Damon T. Leach
T
Tyler J. Sagendorf
A
Abdalla Ahmed
X
Xiaolu Li
M
Matthew J. Gaffrey
I
Isaac K. Attah
H
Hugh D. Mitchell
M
Mark R. Viggars
D
David Gaul
K
Kim M. Huffman
F
Facundo Fernández
DOI：10.1016/j.celrep.2026.117823delete
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Abstract

Abstract

En 中文
• Comprehensive resource of multi-omic skeletal muscle responses to endurance training • Biological sex shapes skeletal muscle training responses primarily at the PTM level • Sex-divergent partitioning of cysteine oxidation across metabolic proteins • Mitochondrial protein networks strongly link to aerobic capacity and lean mass gains
Keywords:
PTMs
endurance exercise
sex differences
cysteine oxidation
skeletal muscle, proteomics
multi-omics
mitochondrial remodeling
post-translational modifications
exercise training
CP: Metabolism
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Journal

Cell Reports cover
Cell Reports
IF:
6.9
Papers:
1.7W
Citations:
10.2W

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