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Terrier: a deep learning repeat classifier

delete2025-08-27
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OA
AI
R
Robert Turnbull
N
Neil D. Young
E
Edoardo Tescari
L
Lee F. Skerratt
T
Tiffany A. Kosch
DOI:10.1093/bib/bbaf442delete
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摘要

摘要

En 中文
摘要 重复DNA序列构成了基因组结构和进化过程的基础,但其准确分类仍然具有挑战性。Terrier是一种深度学习模型,旨在通过利用公开可用且经过整理的重复序列库(在RepeatMasker框架下训练)来对重复DNA序列进行分类,从而克服这些挑战。重复数据库中物种的分类代表性不足,常常限制了当前重复注释方法的分类准确性和可重复性,进而限制了对重复序列进化和功能的理解。Terrier通过利用深度学习提高了准确性,从而克服了这些挑战。该模型在Repbase上进行了训练,Repbase包含超过10万个重复家族(是Dfam的四倍),Terrier将97.1%的Repbase序列映射到RepeatMasker类别,提供了目前最全面的分类系统。在与DeepTE、TERL和TEclass2在模式生物(水稻、果蝇、人类和小鼠)中的基准测试中,Terrier在分类更广泛序列的同时实现了更高的准确率。在非模式生物(两栖动物、扁虫和北极磷虾)基因组中的进一步验证,突显了其在改善非模式物种分类方面的有效性,有助于推动对重复序列驱动的进化、基因组不稳定性和表型变异的研究。

期刊

Briefings in Bioinformatics 封面图
Briefings in Bioinformatics
IF:
7.7
论文数:
5.8K
被引数:
2.7W

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