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Tgf-β receptor signaling cell-intrinsically controls conserved microglia homeostatic maturation during zebrafish development
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DOI：10.1016/j.celrep.2026.117795.png)
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Abstract
En 中文
• Tgf-β signaling requirement for microglia ontogeny is conserved in zebrafish • This signaling acts directly in progenitors to drive microglial differentiation • Both embryonic and adult zebrafish microglia rely on Tgf-β signaling for differentiation • The zebrafish Tgf-β1b paralog controls this process
Keywords:
zebrafish
hematopoiesis
macrophages
microglia
ontogeny
differentiation
signaling
transforming growth factor-β
CP: neuroscience
CP: developmental biology
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