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The chemical profile and cardiovascular effects of Rhinella marina cane toad skin secretion on murine heart
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DOI：10.1080/15569543.2025.2603285.png)
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Abstract
En 中文
Background and aim: The Rhinella marina cane toad from Central and South America is an introduced pest that is now widely distributed throughout Australia. While the cane toad skin secretions are widely known to contain bufadienolides which are digoxin-like compounds, this research investigated other cardioactive compounds that were also present. Experimental approach: Solubilized cane toad skin secretion and HPLC separated fractions were tested in mouse isolated hearts using the Langendorff method. Key findings: Cane toad secretions caused a significant increase in developed pressure, cardiac contraction and heart rate in mouse isolated hearts when compared to digoxin alone (p < 0.05) and was inhibited by the beta-adrenoceptor antagonist propranolol (10 nM, p < 0.05). NMR analysis of HPLC seprated fractions revealed the presence of epinephrine and bufadienolides. Conclusions: The results show that multiple cardioactive agents are present in cane toad secretions with the most profound pharmacological effects caused by epinephrine.
Keywords:
Bufadienolides
cane toad
epinephrine
mouse heart
Rhinella marina
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