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The clinical relevance of regional lymph node microarchitecture in oesophageal cancer patients – Results from the UK MRC OE02 trial
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DOI：10.1016/j.ejca.2026.116910.png)
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Abstract
En 中文
• Neoadjuvant chemotherapy reduces LNneg germinal centre percentage area. • Lower histiocyte proportion in LNneg or LNpos linked to improved overal survival. • Histiocytes in LNneg and LNpos as a novel independent prognostic factor in OeC.
Keywords:
%area
Percentage of lymph node area occupied by respective microarchitecture feature
APC
Antigen presenting cells
CS patients
Patients treated with chemotherapy followed by surgery
OeC
Oesophageal cancer
GermC
Germinal centres
H&E staining
Haematoxylin&eosin staining
LN
Lymph node
LNneg
Tumour-negative lymph node
LNpos
Tumour-containing (=positive) lymph node
N0 patients
Patients with no lymph node metastasis
N1 patients
Patients with lymph node metastasis
OS
Overall survival
PN stage
Pathological lymph node stage Number of LN with metastasis
PT stage
Pathological depth of infiltration of primary tumour in the resection specimen
S patients
Patients treated with surgery alone
TILs
Tumour-infiltrating lymphocytes
Oesophageal cancer
Lymph nodes
Prognostic factor
microarchitecture
Immune system
Survival
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