The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort

2026-08-05

Michael Kammer

Andreas Heinzel

Stephen Shoebridge

Roman Reindl‐Schwaighofer

Karin Hu

Hao Shan Chen

Alexander Kainz

Ismail Daoudi

Ana F. David

Gottfried Fischer

Brendan Keating

Matthias Niemann

Rainer Oberbauer *

DOI：10.1016/j.ebiom.2026.106420

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Kidney transplantation outcomes are strongly influenced by immunological compatibility between donor and recipient. While genetic mismatches in the human leukocyte antigen (HLA) region have long been recognised as key determinants of graft survival, increasing evidence, including our own previous work, suggests that non-HLA alloimmunity also plays a critical role.

Keywords:

Kidney transplantation

Histocompatibility

HLA matching

Graft failure risk

The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort

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