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The cytoplasmic AID complex
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DOI：10.1016/j.smim.2012.05.004.png)
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Although AID fulfils its physiological function of diversifying antibody genes in the nucleus, most of the AID protein within the cell is found in a complex located in the cytoplasm. In this review, we summarize what is currently known about this cytoplasmic AID complex. Its size has been estimated to lie between 300 and 500 kDa (sedimentation coefficient of 10-11 S) and it comprises the abundant protein translation elongation factor its (eEF1A) as a major stoichiometric component. We speculate on the possible roles of this complex as well as of chaperones known to interact with AID in regulating the cytosolic retention of AID and its controlled release for import into the nucleus. (C) 2012 Elsevier Ltd. All rights reserved.
Keyword:
Activation-induced deaminase
AID
Translation elongation factor 1 alpha
eEF1A
Cytoplasmic complex
Antibody diversification
Chaperone
Nuclear:cytoplasmic traffic
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